Next-generation sequencing (NGS) confers the ability to examine a broad array of molecular variants, and enables cancer research by significantly increasing the breadth, sensitivity, and specificity of information obtainable within a single assay. As an increasing number of research and clinical laboratories embrace the power of NGS, Illumina offers simple, comprehensive solutions for producing highquality data necessary for accurate analysis.
Formalin-fixed, paraffin-embedded (FFPE) tissues are a valuable source of material for tumor analysis. However, the formalin fixation and paraffin embedding process impacts nucleic acid quality by fragmenting, cross-linking, and introducing damage through chemical modifications. As the assays used to evaluate DNA and RNA have evolved to obtain more information, the quality and amount of nucleic acid extracted from FFPE material has become more critical for producing high-quality data.
