Through the collaboration of Fujifilm and HORIBA, the Inline Raman Measurement System technology is being enhanced to revolutionize biopharmaceutical production. Further, through Inline Raman Measurement System technology, manufacturers will be able to perform continuous measurements during the cell culture and purification process.The two companies have collaborated to develop the technology that performs real-time analysis inside bioreactors and process systems. Consequently, users of the technology are able to monitor the conditions of the processes without taking samples.
The Inline Raman Measurement System technology has been enhanced by combining HORIBA’s highly sensitive Raman spectroscopy technology with Fujifilm’s unique probe technology. Additionally, Fujifilm has offered its proprietary measuring algorithms for predictive analysis. Thus, through the incorporation of these technologies, the Inline Raman Measurement System offers industry leading measurement sensitivity.
The platform also ensures continuous monitoring for target compounds and any impurities that might be present. In addition, it facilitates faster analysis and better process control in manufacturing processes.
Benefits of New Technology in Yield Optimization and Process Development
Through demonstration tests, Fujifilm was able to confirm the effectiveness of the system. The study found a 10 percent improvement in antibody yields compared to the use of conventional UV-Vis process control systems. The technology recognizes the characteristics of the molecules and creates predictive models using collected information. The manufacturers are then able to determine the appropriate time to collect samples while meeting quality requirements.
In cell culture studies, the technology continuously monitors the concentrations of various amino acids in the growth medium. Such features help manufacturers detect process deviations in order to ensure better quality of their products. The new platform also decreases reliance on classical off-line analytical tools.
The new technology is scheduled to be introduced by Fujifilm at BIO International Convention to be held from 22nd to 25th of June 2026, at San Diego. In the coming years, Fujifilm and HORIBA intend to further validate the technology for widespread industry adoption. Both organizations anticipate that the technology will enhance production efficiency while reducing manufacturing expenses.
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News Source: Businesswire.com
