AstraZeneca and Daiichi Sankyo have started the DESTINY-Endometrial02 trial for Endometrial Cancer. This Phase 3 study evaluates ENHERTU as an adjuvant therapy. It focuses on patients with HER2-expressing types of the disease. This is a vital step for women with high-risk clinical features. Currently, many patients face a high risk of the cancer returning. The study compares the drug against the current standard of care.
Advancing Treatments for Endometrial Cancer
The trial aims to improve outcomes for those with specific biomarkers. Specifically, it targets HER2-positive and HER2-low cases. This marks the first Phase 3 trial for this drug in this setting. Researchers hope to provide a new option for long-term health. Transitioning to targeted therapies could change the future of oncology. Consequently, this study represents a major milestone in women’s healthcare.
“Following the positive results of DESTINY-PanTumor02, which included a cohort of patients with metastatic endometrial cancer, we are now evaluating the use of ENHERTU in earlier lines of treatment for this disease,” said Abderrahmane Laadem, MD, Head, Late-Stage Oncology Clinical Development, Daiichi Sankyo. “We recently initiated DESTINY-Endometrial01 to evaluate ENHERTU as a first-line treatment in patients with HER2 expressing primary advanced or recurrent endometrial cancer and are now initiating DESTINY-Endometrial02, the first trial to investigate a HER2 directed therapy in the adjuvant setting for patients with HER2 expressing endometrial cancer, to explore if ENHERTU can replace current standard of care chemotherapy and improve the long term outcome in this setting.”
Endometrial Cancer remains the second most common gynecologic cancer worldwide. New cases are rising globally every year. Therefore, finding effective early treatments is very important. This drug is a lead ADC in the oncology portfolio. It has already shown success in other types of tumors. Doctors will monitor participants closely during the global trial period. This effort highlights a shared vision for better Endometrial Cancer care.
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News Source: Businesswire.com
